ISCB 43, Newcastle, UK

Mini-symposium of the STRengthening Analytical Thinking for Observational Studies (STRATOS) initiative                                                                                       

Organizers: Willi Sauerbrei (Freiburg, Germany) and Ruth Keogh (London, UK)


Short introduction and overview of the program

Ruth Keogh


Check what is missing with initial data analysis

Lara Lusa (Ljubljana, Slovenia), Kate Lee, Carsten Schmidt, Marianne Huebner for Topic Group: “Initial Data Analysis“ (TG3)


A comparison of three popular methods for handling missing data: complete-case analysis, inverse probability weighting, and multiple imputation

Roderick Little, James Carpenter (London, UK), Katherine Lee for Topic Group: “Missing data” (TG1)


Berkson measurement error and the regression calibration approach

Victor Kipnis (NCI, USA), Laurence Freedman and Pamela Shaw for Topic Group: “Measurement Error and Misclassification” (TG4)

Video file


Comparison of Multivariable Fractional Polynomials with Splines and Penalised Spines

Aris Perperoglou (Newcastle, UK), Daniela Dunkler, Christine Wallisch, Matthias Schmid, Patrick Royston and Willi Sauerbrei for Topic Group: “ Selection of variables and functional forms in multivariable analysis“ (TG2)


Validation of prediction models in the presence of competing risks

Nan van Geloven (Leiden, The Netherlands) - A collaborative project of Topic Groups “Evaluating diagnostic tests and prediction models” (TG6) and “Survival analysis” (TG8)


Use of data-driven simulations to inform real-world survival analyses

Michal Abrahamowicz (Montreal, Canada), Marie-Eve Beauchamp, Anne-Laure Boulesteix, Tim P. Morris, Willi Sauerbrei, Jay S. Kaufman for the Panel on “Simulation Studies”


Developing international standards in the analysis of patient reported outcomes in cancer clinical trials: methodological issues and STRATOS engagement in the European IMI-SISAQOL project

Saskia le Cessie (Leiden, The Netherlands), Els Goetghebeur, Limin Liu, Doranne Thomassen on behalf of work package 3 of the Setting International Standards in Analyzing Patient-Reported Outcomes and Quality of Life Endpoints Data Consortium (SISAQOL)


Discussion about the next steps

Willi Sauerbrei